120-association public preview gene page

MT-CO2

mitochondrially encoded cytochrome c oxidase II

Research use only. This page reports source-attributed evidence observed in the included release data. A gene symbol may appear in more than one rendered disease release. This is not medical advice, diagnosis, treatment guidance, patient risk prediction, clinical decision support, or clinical certainty. It covers only associations included in this release's fixed 120-association preview scope; absence from this page is not evidence of absence.

HGNC:7421 primary gene id

1 associations

1 evidence rows

1 releases

Release Packages

Methods and glossary

dilated-cardiomyopathy-top120-v0.1.0-preview

release directory Git tag Data dictionary integrity.json ZIP archive

Identity

genes.json

Symbol: MT-CO2
Name: mitochondrially encoded cytochrome c oxidase II
Aliases: none in primary release
Provenance: HGNC, Open Targets Platform

Dilated cardiomyopathy

assoc:7421:0005021:355cd676f1ef · dilated-cardiomyopathy-top120-v0.1.0-preview

association row

Status: observed unreviewed
Support tier: single source observed
Review: automatic checks only
Max source-reported score: 0.582

Source Coverage

Supporting sources: Open Targets Platform

Silent sources: ClinVar

Single supporting source with queried-but-silent release source context.

Open Targets Platform: Source-attributed evidence signal; scores are not clinical truth or a combined confidence score. CC0 1.0; citation. Source freshness: refresh recommended; assessed Jun 9, 2026; next review Jul 9, 2026. Snapshot freshness: refresh recommended; assessed Jun 9, 2026; next review Jul 9, 2026; api-v4-graphql-2026-06-14-paper120, 120 records.

Evidence Rows evidence_rows.jsonl

Source	Type	Statement	Open Targets score
Open Targets Platform OT:ENSG00000198712:EFO_0000407	target disease association	Open Targets reports MT-CO2 as associated with dilated cardiomyopathy.	0.582

Open Targets score breakdown

Source-attributed signals reported by Open Targets for OT:ENSG00000198712:EFO_0000407. Each value is Open Targets' own per-datatype or per-datasource score — not truth, clinical validity, or a combined confidence score. Labels such as clinical and clinical_precedence are Open Targets' own datatype and datasource names, not a clinical-use or clinical-validity signal for this association. The overall score is Open Targets' own aggregate over these datasources; because those datasources can overlap with evidence from other sources, the overall score is not an independent line of corroboration.

By datatype

genetic_association 0.786
somatic_mutation 0.684
literature 0.044

By datasource

eva 0.786
eva_somatic 0.684
europepmc 0.044

Caveats

Public-candidate draft; research-use only and not a clinical finding.
AI/referee review artifacts are advisory and do not replace human scientific review.
Open Targets scores are source-attributed evidence signals, not truth or clinical validity scores.
Open Targets target-disease association context is not diagnostic, treatment, or clinical decision-making guidance.
Single-source Open Targets evidence has not passed review gates.

Source names identify provenance only and do not imply endorsement by HGNC, MONDO, Open Targets, ClinVar, NCBI, or any upstream source.