120-association public preview gene page

PALB2

partner and localizer of BRCA2

Research use only. This page reports source-attributed evidence observed in the included release data. A gene symbol may appear in more than one rendered disease release. This is not medical advice, diagnosis, treatment guidance, patient risk prediction, clinical decision support, or clinical certainty. It covers only associations included in this release's fixed 120-association preview scope; absence from this page is not evidence of absence.

HGNC:26144 primary gene id

1 associations

1 evidence rows

1 releases

Release Packages

Methods and glossary

breast-carcinoma-top120-v0.1.0-preview

release directory Git tag Data dictionary integrity.json ZIP archive

Identity

genes.json

Symbol: PALB2
Name: partner and localizer of BRCA2
Aliases: none in primary release
Provenance: HGNC, Open Targets Platform

Breast carcinoma

assoc:26144:0004989:f3de2cac6d71 · breast-carcinoma-top120-v0.1.0-preview

association row

Status: observed unreviewed
Support tier: single source observed
Review: automatic checks only
Max source-reported score: 0.867

Source Coverage

Supporting sources: Open Targets Platform

Silent sources: ClinVar

Single supporting source with queried-but-silent release source context.

Open Targets Platform: Source-attributed evidence signal; scores are not clinical truth or a combined confidence score. CC0 1.0; citation. Source freshness: refresh recommended; assessed Jun 9, 2026; next review Jul 9, 2026. Snapshot freshness: refresh recommended; assessed Jun 9, 2026; next review Jul 9, 2026; api-v4-graphql-2026-06-14-paper120, 120 records.

Evidence Rows evidence_rows.jsonl

Source	Type	Statement	Open Targets score
Open Targets Platform OT:ENSG00000083093:EFO_0000305	target disease association	Open Targets reports PALB2 as associated with breast carcinoma.	0.867

Open Targets score breakdown

Source-attributed signals reported by Open Targets for OT:ENSG00000083093:EFO_0000305. Each value is Open Targets' own per-datatype or per-datasource score — not truth, clinical validity, or a combined confidence score. Labels such as clinical and clinical_precedence are Open Targets' own datatype and datasource names, not a clinical-use or clinical-validity signal for this association. The overall score is Open Targets' own aggregate over these datasources; because those datasources can overlap with evidence from other sources, the overall score is not an independent line of corroboration.

By datatype

genetic_association 0.945
genetic_literature 0.905
somatic_mutation 0.841
literature 0.463

By datasource

genomics_england 0.979
eva 0.969
gene_burden 0.922
cancer_gene_census 0.841
gwas_credible_sets 0.773
uniprot_literature 0.608
europepmc 0.463

Caveats

Public-candidate draft; research-use only and not a clinical finding.
AI/referee review artifacts are advisory and do not replace human scientific review.
Open Targets scores are source-attributed evidence signals, not truth or clinical validity scores.
Open Targets target-disease association context is not diagnostic, treatment, or clinical decision-making guidance.
Single-source Open Targets evidence has not passed review gates.

Source names identify provenance only and do not imply endorsement by HGNC, MONDO, Open Targets, ClinVar, NCBI, or any upstream source.